A formalized framework for mobile cloud computing

Mobile Cloud Computing (MCC) is an emerging paradigm to transparently provide support for demanding tasks on resource-constrained mobile devices by relying on the integration with remote cloud services. Research in this field is tackling the multiple conceptual and technical challenges (e.g., how and when to offload) that are hindering the full realization of MCC. The Networked Autonomic Machine (NAM) framework is a tool that supports and facilitates the design networks of hardware and software autonomic entities, providing or consuming services or resources. Such a framework can be applied, in particular, to MCC scenarios. In this paper, we focus on NAM’s features related to the key aspects of MCC, in particular those concerning code mobility capabilities and autonomic offloading strategies. Our first contribution is the definition of a set of high-level actions supporting MCC. The second contribution is the proposal of a formal semantics for those actions, which provides the core NAM features with a precise formal characterization. Thus, the third contribution is the further development of the NAM conceptual framework and, in particular, the partial re-engineering of the related Java middleware. We show the effectiveness of the revised middleware by discussing the implementation of a Global Ambient Intelligence case study

NEMO: A flexible and highly scalable network EMulatOr

Evaluating novel applications and protocols in realistic scenarios has always been a very important task for all stakeholders working in the networking field. Network emulation, being a trade-off between actual deployment and simulations, represents a very powerful solution to this issue, providing a working network platform without requiring the actual deployment of all network components. We present NEMO, a flexible and scalable Java-based network emulator, which can be used to emulate either only a single link, a portion of a network, or an entire network. NEMO is able to work in both real and virtual time, depending on the tested scenarios and goals, and it can be run as either a stand-alone instance on a single machine, or distributed among different network-connected machines, leading to distributed and highly scalable emulation infrastructures. Among different features, NEMO is also capable of virtualizing the execution of third-party Java applications by running them on top of virtual nodes, possibly attached to an emulated or external network. Keywords: Network emulation, Protocol stack, Jav

Mechanical behaviour and phase transition mechanisms of a shape memory alloy by means of a novel analytical model

The aim of the present paper is to examine both the fatigue behaviour and the phase transition mechanisms of an equiatomic pseudo-elastic NiTi Shape Memory Alloy through cyclic tests (up to 100 loading cycles). More precisely, miniaturised dog-bone specimens are tested by using a customised testing machine and the contents of both austenite and martensite phase are experimentally measured by means of X-Ray diffraction (XRD) analyses. On the basis of such experimental results in terms of martensite content, an analytical model is here formulated to correlate the stress-strain relationship to the phase transition mechanisms. Finally, a validation of the present model by means of experimental data pertaining the stress-strain relationship is performed

Secreted phospholipases A2 in hereditary angioedema with C1-inhibitor deficiency

BackgroundHereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that patients with C1-INH-HAE have increased plasma levels of vascular endothelial growth factors and angiopoietins (Angs), which have been associated with vascular permeability in several diseases. Among these and other factors, blood endothelial cells and vascular permeability can be modulated by extracellular or secreted phospholipases A2 (sPLA2s).ObjectiveWe sought to investigate the enzymatic activity and biological functions of sPLA2 in patients with C1-INH-HAE.MethodssPLA2s enzymatic activity was evaluated in the plasma from 109 adult patients with C1-INH-HAE and 68 healthy donors in symptom-free period and attacks. Plasma level of group IIA sPLA2 (hGIIA) protein was measured in selected samples. The effect of C1-INH-HAE plasma on endothelial permeability was examined in vitro using a vascular permeability assay. The role of hGIIA was determined using highly specific sPLA2 indole inhibitors. The effect of recombinant hGIIA on C1-INH activity was examined in vitro by functional assay.ResultsPlasma sPLA2 activity and hGIIA levels are increased in symptom-free C1-INH-HAE patients compared with controls. sPLA2 activity negatively correlates with C1-INH protein level and function. C1-INH-HAE plasma increases endothelial permeability in vitro, and this effect is partially reverted by a specific hGIIA enzymatic inhibitor. Finally, recombinant hGIIA inhibits C1-INH activity in vitro.ConclusionsPLA2 enzymatic activity (likely attributable to hGIIA), which is increased in C1-INH-HAE patients, can promote vascular permeability and impairs C1-INH activity. Our results may pave the way for investigating the functions of sPLA2s (in particular, hGIIA) in the pathophysiology of C1-INH-HAE and may inform the development of new therapeutic targets

A transcriptomic study of Hereditary Angioedema attacks

Background: Hereditary angioedema (HAE) caused by C1-inhibitor deficiency is a lifelong illness characterized by recurrent acute attacks of localized skin or mucosal edema. Activation of the kallikrein/bradykinin pathway at the endothelial cell level has a relevant pathogenetic role in acute HAE attacks. Moreover, other pathways are involved given the variable clinical expression of the disease in different patients. Objective: We sought to explore the involvement of other putative genes in edema formation. Methods: We performed a PBMC microarray gene expression analysis on RNA isolated from patients with HAE during an acute attack and compared them with the transcriptomic profile of the same patients in the remission phase. Results: Gene expression analysis identified 23 genes significantly modulated during acute attacks that are involved primarily in the natural killer cell signaling and leukocyte extravasation signaling pathways. Gene set enrichment analysis showed a significant activation of relevant biological processes, such as response to external stimuli and protein processing (q < 0.05), suggesting involvement of PBMCs during acute HAE attacks. Upregulation of 2 genes, those encoding adrenomedullin and cellular receptor for urokinase plasminogen activator (uPAR), which occurs during an acute attack, was confirmed in PBMCs of 20 additional patients with HAE by using real-time PCR. Finally, in vitro studies demonstrated the involvement of uPAR in the generation of bradykinin and endothelial leakage. Conclusions: Our study demonstrates the increase in levels of adrenomedullin and uPAR in PBMCs during an acute HAE attack. Activation of these genes usually involved in regulation of vascular tone and in inflammatory response might have a pathogenic role by amplifying bradykinin production and edema formation in patients with HAE

life expectancy in italian patients with hereditary angioedema due to c1 inhibitor deficiency

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A public data archive for the Italian radio telescopes

The amount of data delivered by modern instrumentation and observing techniques is bringing radio astronomy in the era of Big Data, and the nowadays widely adopted Open Data policies allow free and open access to data from many radio astronomy facilities. A fundamental ingredient to enable Open Science in the radio astronomical community and to engage also public participation (the so called Citizen Science) is thus the availability of public archives in which data can be accessed and searched with modern software tools. A web-based, VO-compliant public archive has been built to host data from the Italian radio telescopes managed by the National Institute for Astrophysics (INAF). The archive main features consist in the capability to handle the various types of data coming from the different observing instrumentation at the telescopes; the adoption of a policy to guarantee the data proprietary period; the accessibility of data through a web interface and the adoption of VO standards to allow for successful scientific exploitation of the archive itself in the data mining era. We present the progress status of the public Data Archive for the Italian radio telescopes being developed to provide the international community with a state-of-the-art archive for radio astronomical data